The article discusses Orientalism in Islamic perspective and sees how this trend of writing has evolved through colonial and post-colonial era. It also discusses the influence of Orientalists in European and American academia in shaping Middle Eastern Studies and Near Eastern Studies departments. The article underscores the political and colonial dimensions of the whole movement of the Orientalist methodology that still dominates research in American universities. Relationship between Orientalist scholarship and political hegemony is also highlighted. Views of non-Western scholars such as Abdullah Laroui and Anwer Abdul Malek and Abdul Latif Tibawi against Orientalist scholarship reflects how politics of knowledge in the field of Islamic Studies has always been shadowed by prejudice, racism stereotyping and biases.